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The incidence rate of central nervous system tumors in the USA is 14.8/100,000 people per year.1 Within these, the malignant CNS tumors are accountable for at least 12,760 deaths for the year 2005 (1). The CNS tumors incidence in the USA is associated with male gender, Caucasian race, metropolitan area residents, and the elderly population (2). CNS tumor incidence in the USA has been studied and reported using centralized databases and registries. The Central Brain Tumor Registry of the United States (CBTRUS), the Surveillance, Epidemiology and End Results (SEER) Program and the North America Association of Central Cancer Registry (NAACCR) are among the most important sources of information available in the USA (3). They have been widely utilized for epidemiologic and cancer research studies (4-7). Regarding CNS tumors, the general assumption in Puerto Rico is that the incidence and epidemiological profile is similar to those found in the USA. However, the demographical, ethnic and geographic characteristics of Puerto Rico may point towards a unique histopathological distribution of CNS tumors. It has been suggested in the literature a difference in the incidence rate of CNS tumors in different countries (2, 8-11), However, there is a lack of medical statistics, literature, or documented epidemiologic information to substantiate any assumption regarding CNS tumors in PR. Moreover, it is important to note that there are only few studies of brain tumors available for Latin American, and Caribbean countries, including Puerto Rico (12-15). The authors are only aware of only one published study regarding the incidence, risk factors and survival of CNS tumors in Puerto Rico (15). Puerto Rico has only one centralized cancer registry. In the past, this registry only collected information regarding malignant tumors. Since 2004, the Puerto Rico Central Cancer Registry (PRCCR) has been collecting data on Descriptive Profile of Surgically-confirmed Adult Central Nervous System Tumors in Puerto Rico